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TMG, or its child, DMG, provides methyl groups, thus helping wash the 4-OHE downstream. IF (and it's a big IF) this is true, in vivo, DIM should not be taken without a methyl donor, and would be especially dangerous in someone with a COMT enzyme deficiency. Betaine is converted into DMG as it donates a methyl group to homocysteine. This pathway is mediated by BHMT, an enzyme induced by betaine and inhibited by DMG or SAM. A small amount of DMG is eliminated in the urine, and most DMG is converted via DMG-dehydrogenase into sarcosine and glycine.
Three Variations from Manual to Fully Automatic
The UNO tool presetter provides accurate measurement of tools up to 400 mm in diameter and 400 mm in length. It features a FEM-optimized and thermally stable construction. The UNO is available in 3 variations: UNO 20 | 40 for manual measurement, UNO 20 | 40 autofocus for semi-automatic measurement that offers the automatic focusing of the tool tip, and UNO 20 | 70 automatic drive for fully automatic measurement of even complex-shaped tools.
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